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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Hirano body ： ウィキペディア英語版 Hirano body Hirano bodies are intracellular aggregates of actin and actin-associated proteins first observed in neurons (nerve cells) by Asao Hirano in 1965.〔( University of Edinburgh ), (Hirano bodies ), citing Hirano, Asao. (1965) "Pathology of amyotrophic lateral sclerosis," in ''Slow Latent and Temperate Virus Infections,'' National Institute of Neurological Diseases and Blindness (NINDB) monograph No.2, pp. 23-37.〕 Hirano bodies are found in the nerve cells of individuals afflicted with certain neurodegenerative disorders, such as Alzheimer's disease and Creutzfeldt-Jakob disease.〔Cartier, L, Galvez, S. and Gajdusek, D.C. (1985). "Familial clustering of the ataxic form of Creutzfeldt-Jacob disease with Hirano bodies," ''J.Neurol.Neurosurg.Psychiatry'' 48(3), pp. 234-238.〕 Hirano bodies are often described as rod-shaped, crystal-like, and eosinophilic (pink after staining with haematoxylin and eosin). They are frequently seen in hippocampal pyramidal cells. An experimental model of Hirano body formation has been reported, using a genetically altered strain of the slime mold ''Dictyostelium discoideum''.〔Maselli, A. G., Davis, R., Furukawa, R. and Fechheimer, M. (2002)."Formation of Hirano bodies in Dictyostelium and mammalian cells induces by expression of a modified form of an actin-crosslinking protein," ''J.Cell Sci.'' 115, 1939-1952.〕 Hirano bodies have been noted as a function of age without obvious underlying neurodegeration.〔Gibson, P. H. and Tomlinson, B. E. (1977). "Numbers of Hirano bodies in the hippocampus of normal and demented people with Alzheimer's disease," ''J.Neurol.Sci.'' 33, 199-206.〕 ==Notes== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Hirano body」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.